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NEUROPATHIES FROM BORDETELLA
PERTUSSIS:
Multiple sclerosis (MS); Amyotrophic Lateral Sclerosis (ALS);
Non-Patched Neuropathies (NPN)
G.M.P., 38 years old. He was admitted (Genuary 2002) in the Division
for Infective Diseases in one of the most famous public hospital, in the
northern part of Italy, to exclude the eventual infective etiology of
two demyelinating lesions of the white substance (the first one was revealed
by RMN in Genuary 2000; the second one in December 2001). Among the various
tests which were made, there were the following: titration of neutrophils
anti cytoplasm (ANCA): absent; research for Aspergillus antigen: negative;
research for anti-Aspergillus antibodies: negative; IgG anti-CMV: 5,5;
IgM anti-CMV: absent; IgG anti HSV1 e HSV2: absent; IgM anti-HVS: absent;
IgG anti-VCA-EBV: 4,0; IgM anti-VCA-EBV: absent; IgG anti-VZV: 2,3; IgM
anti-VZV: absent; IgG anti-toxoplasma: < 4; IgM anti-toxoplasma: absent;
research for Cryptococcus antigen, negative; CMV-IEA: negative; anti-Borrelia
Burgdorferi antibodies: absent; Lue serology: negative; parasitic test
of feces: negative; anti-HIV1/2 antibodies: absent; Widal-Wright: negative.
Cerebrospinal Fluid: Limpid aspect, colourless, albumin: 36,3; IgG: 4,23;
nucleated elements < 1 ; viral DNA reaserch in the Liquor: negative
for HSV1, HSV2, CMV, EBV, HVZ, HHV6, JCV; cultural test: negative; reaserch
for Oligoclonal Bands: negative. Final issue of Specialists: the test
executed during the admission period excluded the infective etiology.
After the dismissal, the patient asked for an anti-Bordetella Pertussis
antibodies research. Results: anti Bordetella IgG 0,64 O.D., cut-off 0,56
O.D., Absorbance 11,40 (positive ³ 8 ); anti Bordetella IgM 0,14
O.D., cut-off 0,27 O.D., Absorbance 5,18); anti Filamentous H.A. IgA 0,93
O.D. (positive for infection caused by Bordetella Pertussis
in S-phase ³ 0,30 O.D.); anti Filamentous H.A. IgG 0,65 O.D.; anti
Pertussis Toxin IgA 0,29 O.D.; anti Pertussis Toxin IgG 0,30 O.D. Report
of Pesaro Civil Hospital: very recent infection.
Having found (See notes 1 - 6) positive
the research for anti-Bordetella antibodies in the 95.47 % of 92 patients
affected by defined MS (patients not selected for the clinical form and
for the therapeutical treatment) and in the 100 % of 41 patients affected
by NPN (Amyotrophic Lateral Sclerosis, Pseudobulbar Syndrome, Motoneuron
Disease, Neurogenous Muscolar Dystrophy; Hemiparkinson, Spastic Tetraparesis,
Balo's Concentric Sclerosis):
after the test made by Acqui Terme ASL 22 7 [in 25 patients with defined
MS: 11 came out to be affected by an acting infection by Bordetella Pertussis
on S-phase (Bordetella in S-phase is virulent and contagious); 14 came
out to be affected by an acting infection by Bordetella Pertussis on R-phase].
I reassessed the pathogenesis of the neuropathies from Bordetella Pertussis:
- In MS, the astrocytes are producers of II-class HLA-Antigens
and make the endothelia expose adhesion molecules. The immune circulating
complexes (ICC), "kept" by adhesion molecules, precipitate in
the central nervous system: we have MS (damages from ICC precipitation
= patches).
- In NPN (ALS), astrocytes are not producers of II-class HLA-Antigens;
the endothelia of cerebral vessels do not expose adhesion molecules. The
persistence in circulation of most part of ICC which form up, leads to
their progressive increase, so that, in the end, the inhibitory mechanisms
that ICC themselves trigger off in the production of antibodies are onset.
In chronic pertussis infections, in subjects with astrocytes non-producers
of II-class HLA-Antigens, during the inhibiting phases from immune complexes
(relative lack of antibodies), Bordetella toxins go into blood and fix
themselves directly on neuroepithelia: we have neuropathies without patches.
The pathogenic power of the various pertussis toxins perfectly explains
the neuroepithelial damages characteristic of the neuropathies without
patches.
Implication: after the test made by Acqui Terme ASL 22 (See
note 7) and the clamorous confirmation of the exposed case, no
Doctor will have the right to ignore the results of my research exposing
to disability patients who, after a simple blood test, could be rationally
treated.
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