MULTIPLE SCLEROSIS
Definition
The Multiple Sclerosis is a toxi-infective disease from barrier defect: the environmental factor
is constituted by Bordetella; the individual factors are the muco-ciliar barrier defect and the
astrocytes phenotype (II class Ag-HLA producers).
Summary
Reassessing the role of Bordetella toxins in inducing experimental allergic encephalitis, revisited the pertussis physiopathology of newborn from hyperimmune mother and the pathology from immune complexes, I searched for anti-Bordetella antibodies in different groups of patients with Multiple Sclerosis (MS).
The results demonstrate that in the 90 % of 40 patients with chronic-evolutive MS, an infection by Bordetella Pertussis is taking place and that in the 94,57 % of 92 MS-patients, not selected for clinic form, there are abnormal levels of antipertussis antibodies in the serum.
This suggest that in MS:
- the environmental factor is Bordetella;
- the individual factor, sine qua non, is a muco-ciliar barrier defect;
- a specific antibiotic treatment is mandatory to stop the course of the disease and prevent severe disability.
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